Protein name:
Dentin matrix acidic phosphoprotein 1 (DMP-1;Dentin matrix protein 1) ;
Alternative:
AG1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with importin alpha.
Function:
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Subcellular Location:
Nucleus
Cytoplasm
Secreted
extracellular space
extracellular matrix
In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Protein Attributes:
50:
MKTVILLTFL | WGLSCALPVA | RYQNTESESS | EERTGNLAQS | PPPPMANSDH |
100:
TDSSESGEEL | GSDRSQYRPA | GGLSKSAGMD | ADKEEDEDDS | GDDTFGDEDN |
150:
GPGPEERQWG | GPSRLDSDED | SADTTQSSED | STSQENSAQD | TPSDSKDHHS |
200:
DEADSRPEAG | DSTQDSESEE | YRVGGGSEGE | SSHGDGSEFD | DEGMQSDDPG |
250:
STRSDRGHTR | MSSAGIRSEE | SKGDHEPTST | QDSDDSQDVE | FSSRKSFRRS |
300:
RVSEEDDRGE | LADSNSRETQ | SVSTEDFRSK | EESRSETQED | TAETQSQEDS |
350:
PEGQDPSSES | SEEAGEPSQE | SSSESQEGVA | SESRGDNPDN | TSQTGDQRDS |
400:
ESSEEDRLNT | FSSSESQSTE | EQGDSESNES | LSLSEESQES | AQDEDSSSQE |
450:
GLQSQSASRE | SRSQESQSEQ | DSRSEENRDS | DSQDSSRSKE | ESNSTGSTSS |
489:
SEEDNHPKNI | EADNRKLIVD | AYHNKPIGDQ | DDNDCQDGY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Polyclonal Antibody for Rat DMP-1
Polyclonal Antibody for Rat DMP-1
Polyclonal Antibody for Rat DMP-1
Polyclonal Antibody for Rat DMP-1
Monoclonal Antibody for Rat DMP-1
Monoclonal Antibody for Rat DMP-1
Monoclonal Antibody for Rat DMP-1
Monoclonal Antibody for Rat DMP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Tooth .